Myeloperoxidase-Specific Plasma Cell Depletion by Bortezomib Protects from Anti-Neutrophil Cytoplasmic Autoantibodies–Induced Glomerulonephritis

Anti-neutrophil cytoplasmic autoantibodies (ANCA) cause vasculitis and necrotizing crescentic glomerulonephritis (NCGN). Steroids and cytotoxic drugs reduce mortality but can cause significant adverse events. The proteasome inhibitor bortezomib (BTZ) prevents glomerulonephritis in mouse models of lu...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Bontscho, Julia, Schreiber, Adrian, Manz, Rudolf A., Schneider, Wolfgang, Luft, Friedrich C., Kettritz, Ralph
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Nephrology 2011
विषय:
Basic Research
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029906/
https://ncbi.nlm.nih.gov/pubmed/21233415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010010034
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