Myeloperoxidase-Specific Plasma Cell Depletion by Bortezomib Protects from Anti-Neutrophil Cytoplasmic Autoantibodies–Induced Glomerulonephritis

Anti-neutrophil cytoplasmic autoantibodies (ANCA) cause vasculitis and necrotizing crescentic glomerulonephritis (NCGN). Steroids and cytotoxic drugs reduce mortality but can cause significant adverse events. The proteasome inhibitor bortezomib (BTZ) prevents glomerulonephritis in mouse models of lu...

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Detalhes bibliográficos
Main Authors: Bontscho, Julia, Schreiber, Adrian, Manz, Rudolf A., Schneider, Wolfgang, Luft, Friedrich C., Kettritz, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2011
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029906/
https://ncbi.nlm.nih.gov/pubmed/21233415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010010034
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