Myeloperoxidase-Specific Plasma Cell Depletion by Bortezomib Protects from Anti-Neutrophil Cytoplasmic Autoantibodies–Induced Glomerulonephritis

Anti-neutrophil cytoplasmic autoantibodies (ANCA) cause vasculitis and necrotizing crescentic glomerulonephritis (NCGN). Steroids and cytotoxic drugs reduce mortality but can cause significant adverse events. The proteasome inhibitor bortezomib (BTZ) prevents glomerulonephritis in mouse models of lu...

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Autori principali: Bontscho, Julia, Schreiber, Adrian, Manz, Rudolf A., Schneider, Wolfgang, Luft, Friedrich C., Kettritz, Ralph
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2011
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029906/
https://ncbi.nlm.nih.gov/pubmed/21233415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010010034
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