Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

Chronic granulomatous disease (CGD) is an inherited disorder characterized by recurrent infections and deregulated inflammatory responses. CGD is caused by mutations in subunits of the NADPH oxidase, an enzyme that generates reactive oxygen species in phagocytes. To elucidate the contribution of the...

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Detalhes bibliográficos
Main Authors: Meissner, Felix, Seger, Reinhard A., Moshous, Despina, Fischer, Alain, Reichenbach, Janine, Zychlinsky, Arturo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938844/
https://ncbi.nlm.nih.gov/pubmed/20495074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-264218
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