A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40(phox) and selective defects in neutrophil NADPH oxidase activity

Chronic granulomatous disease (CGD), an immunodeficiency with recurrent pyogenic infections and granulomatous inflammation, results from loss of phagocyte superoxide production by recessive mutations in any 1 of 4 genes encoding subunits of the phagocyte NADPH oxidase. These include gp91(phox) and p...

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Bibliographic Details
Main Authors: Matute, Juan D., Arias, Andres A., Wright, Nicola A. M., Wrobel, Iwona, Waterhouse, Christopher C. M., Li, Xing Jun, Marchal, Christophe C., Stull, Natalie D., Lewis, David B., Steele, MacGregor, Kellner, James D., Yu, Weiming, Meroueh, Samy O., Nauseef, William M., Dinauer, Mary C.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Phagocytes, Granulocytes, and Myelopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759653/
https://ncbi.nlm.nih.gov/pubmed/19692703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-231498
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