p47(phox) Phox Homology Domain Regulates Plasma Membrane but Not Phagosome Neutrophil NADPH Oxidase Activation

The assembly of cytosolic subunits p47(phox), p67(phox), and p40(phox) with flavocytochrome b(558) at the membrane is required for activating the neutrophil NADPH oxidase that generates superoxide for microbial killing. The p47(phox) subunit plays a critical role in oxidase assembly. Recent studies...

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Main Authors: Li, Xing Jun, Marchal, Christophe C., Stull, Natalie D., Stahelin, Robert V., Dinauer, Mary C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Membrane Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966130/
https://ncbi.nlm.nih.gov/pubmed/20817944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.164475
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