FcγR-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40(phox) regulates NADPH oxidase activity after enzyme assembly on the phagosome

The phagocyte NADPH oxidase generates superoxide for microbial killing, and includes a membrane-bound flavocytochrome b(558) and cytosolic p67(phox), p47(phox), and p40(phox) subunits that undergo membrane translocation upon cellular activation. The function of p40(phox), which binds p67(phox) in re...

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Detalhes bibliográficos
Main Authors: Tian, Wei, Li, Xing Jun, Stull, Natalie D., Ming, Wenyu, Suh, Chang-Il, Bissonnette, Sarah A., Yaffe, Michael B., Grinstein, Sergio, Atkinson, Simon J., Dinauer, Mary C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Phagocytes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572805/
https://ncbi.nlm.nih.gov/pubmed/18711001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-126029
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