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The armadillo repeat domain of Apc suppresses intestinal tumorigenesis
The adenomatous polyposis coli (APC) gene is known to act as a tumor suppressor gene in both sporadic and hereditary colorectal cancer by negatively regulating WNT signaling. Familial adenomatous polyposis (FAP) patients develop intestinal polyps due to the presence of a single germline mutation in...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3025611/ https://ncbi.nlm.nih.gov/pubmed/20886217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00335-010-9288-0 |
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