Cancer Stemness in Apc- vs. Apc/KRAS-Driven Intestinal Tumorigenesis

Constitutive activation of the Wnt pathway leads to adenoma formation, an obligatory step towards intestinal cancer. In view of the established role of Wnt in regulating stemness, we attempted the isolation of cancer stem cells (CSCs) from Apc- and Apc/KRAS-mutant intestinal tumours. Whereas CSCs ar...

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Detalhes bibliográficos
Main Authors: Ghazvini, Mehrnaz, Sonneveld, Petra, Kremer, Andreas, Franken, Patrick, Sacchetti, Andrea, Atlasi, Yaser, Roth, Sabrina, Joosten, Rosalie, Smits, Ron, Fodde, Riccardo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775784/
https://ncbi.nlm.nih.gov/pubmed/24069241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073872
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