A Targeted Constitutive Mutation in the Apc Tumor Suppressor Gene Underlies Mammary But Not Intestinal Tumorigenesis

Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of multiple colorectal adenomas and of a broad spectrum of extra-intestinal tumors. Moreover, somatic APC mutat...

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Detalhes bibliográficos
Main Authors: Gaspar, Claudia, Franken, Patrick, Molenaar, Lia, Breukel, Cor, van der Valk, Martin, Smits, Ron, Fodde, Riccardo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697381/
https://ncbi.nlm.nih.gov/pubmed/19578404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000547
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