β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis

OBJECTIVE: Deregulation of the Wnt signalling pathway by mutations in the Apc or β-catenin genes underlies colorectal carcinogenesis. As a result, β-catenin stabilises, translocates to the nucleus, and activates gene transcription. Intestinal tumours show a heterogeneous pattern of nuclear β-catenin...

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Detalhes bibliográficos
Main Authors: van Veelen, Wendy, Le, Ngoc H, Helvensteijn, Werner, Blonden, Lau, Theeuwes, Myrte, Bakker, Elvira R M, Franken, Patrick F, van Gurp, Léon, Meijlink, Frits, van der Valk, Martin A, Kuipers, Ernst J, Fodde, Riccardo, Smits, Ron
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2011
Assuntos:
GI neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152867/
https://ncbi.nlm.nih.gov/pubmed/21307168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2010.233460
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