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β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis
OBJECTIVE: Deregulation of the Wnt signalling pathway by mutations in the Apc or β-catenin genes underlies colorectal carcinogenesis. As a result, β-catenin stabilises, translocates to the nucleus, and activates gene transcription. Intestinal tumours show a heterogeneous pattern of nuclear β-catenin...
Tallennettuna:
Päätekijät: | , , , , , , , , , , , , |
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Aineistotyyppi: | Artigo |
Kieli: | Inglês |
Julkaistu: |
BMJ Group
2011
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Aiheet: | |
Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3152867/ https://ncbi.nlm.nih.gov/pubmed/21307168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2010.233460 |
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