Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

The adenomatous polyposis coli (APC) gene is considered as the true gatekeeper of colonic epithelial proliferation: It is mutated in the majority of colorectal tumors, and mutations occur at early stages of tumor development in mouse and man. These mutant proteins lack most of the seven 20-amino-aci...

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Detalhes bibliográficos
Main Authors: Smits, Ron, Kielman, Menno F., Breukel, Cor, Zurcher, Chris, Neufeld, Kristi, Jagmohan-Changur, Shantie, Hofland, Nandy, van Dijk, Jaap, White, Ray, Edelmann, Winfried, Kucherlapati, Raju, Khan, P. Meera, Fodde, Riccardo
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1999
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC316713/
https://ncbi.nlm.nih.gov/pubmed/10346819
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