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Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

The adenomatous polyposis coli (APC) gene is considered as the true gatekeeper of colonic epithelial proliferation: It is mutated in the majority of colorectal tumors, and mutations occur at early stages of tumor development in mouse and man. These mutant proteins lack most of the seven 20-amino-aci...

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Udgivet i:Genes Dev
Principais autores: Smits, Ron, Kielman, Menno F., Breukel, Cor, Zurcher, Chris, Neufeld, Kristi, Jagmohan-Changur, Shantie, Hofland, Nandy, van Dijk, Jaap, White, Ray, Edelmann, Winfried, Kucherlapati, Raju, Khan, P. Meera, Fodde, Riccardo
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1999
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316713/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10346819/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.10.1309
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