Endothelial cell talin1 is essential for embryonic angiogenesis

Using Tln1(fl/fl);CreER mice, we show that tamoxifen-induced inactivation of the talin1 gene throughout the embryo produces an angiogenesis phenotype that is restricted to newly forming blood vessels. The phenotype has a rapid onset in early embryos, resulting in vessel defects by 48 h and death of...

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Main Authors: Monkley, Susan J., Kostourou, Vassiliki, Spence, Lorraine, Petrich, Brian, Coleman, Stacey, Ginsberg, Mark H., Pritchard, Catrin A., Critchley, David R.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025397/
https://ncbi.nlm.nih.gov/pubmed/21081121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2010.11.010
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