Talin1 and Rap1 Are Critical for Osteoclast Function

To determine talin1's role in osteoclasts, we mated TLN1(fl/fl) mice with those expressing cathepsin K-Cre (CtsK-TLN1) to delete the gene in mature osteoclasts or with lysozyme M-Cre (LysM-TLN1) mice to delete TLN1 in all osteoclast lineage cells. Absence of TLN1 impairs macrophage colony-stimu...

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Detalhes bibliográficos
Main Authors: Zou, Wei, Izawa, Takashi, Zhu, Tingting, Chappel, Jean, Otero, Karel, Monkley, Susan J., Critchley, David R., Petrich, Brian G., Morozov, Alexei, Ginsberg, Mark H., Teitelbaum, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571341/
https://ncbi.nlm.nih.gov/pubmed/23230271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00790-12
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