Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

In inflammation, neutrophils and other leukocytes roll along the microvascular endothelium before arresting and transmigrating into inflamed tissues. Arrest requires conformational activation of the integrin lymphocyte function-associated antigen-1 (LFA-1). Mutations of the FERMT3 gene encoding kind...

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Detalhes bibliográficos
Main Authors: Lefort, Craig T., Rossaint, Jan, Moser, Markus, Petrich, Brian G., Zarbock, Alexander, Monkley, Susan J., Critchley, David R., Ginsberg, Mark H., Fässler, Reinhard, Ley, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359742/
https://ncbi.nlm.nih.gov/pubmed/22431571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-373118
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