LFA-1, kindlin-3 and calcium flux orchestrate neutrophil recruitment during inflammation

Neutrophil arrest and migration on inflamed endothelium involves a conformational shift in CD11a/CD18 (LFA-1) to a high affinity and clustered state that determines the strength and lifetime of bond formation with ICAM-1. Cytoskeletal adaptor proteins Kindlin-3 and Talin-1 anchor clustered LFA-1 to...

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Hlavní autoři: Dixit, Neha, Kim, Min-ho, Rossaint, Jan, Yamayoshi, Itsukyo, Zarbock, Alexander, Simon, Scott I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723394/
https://ncbi.nlm.nih.gov/pubmed/23144497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201638
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