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LFA-1, kindlin-3 and calcium flux orchestrate neutrophil recruitment during inflammation

Neutrophil arrest and migration on inflamed endothelium involves a conformational shift in CD11a/CD18 (LFA-1) to a high affinity and clustered state that determines the strength and lifetime of bond formation with ICAM-1. Cytoskeletal adaptor proteins Kindlin-3 and Talin-1 anchor clustered LFA-1 to...

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Bibliografiske detaljer
Main Authors: Dixit, Neha, Kim, Min-ho, Rossaint, Jan, Yamayoshi, Itsukyo, Zarbock, Alexander, Simon, Scott I.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723394/
https://ncbi.nlm.nih.gov/pubmed/23144497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201638
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