Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow

Orai1 was reported to function as a calcium channel subunit that facilitates store operated calcium entry (SOCE) in T cells and is necessary for formation of the immune synapse. We reasoned that SOCE via Orai1 might regulate PMNs activation during recruitment to inflamed endothelium. Orai1 function...

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Bibliographic Details
Main Authors: Schaff, Ulrich Y., Dixit, Neha, Procyk, Emily, Yamayoshi, Itsukyo, Tse, Tiffany, Simon, Scott I.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2010
Subjects:
Phagocytes, Granulocytes, and Myelopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810981/
https://ncbi.nlm.nih.gov/pubmed/19965684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-224659
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