Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice

The majority of peripheral serotonin is stored in platelets, which secrete it on activation. Serotonin releases Weibel-Palade bodies (WPBs) and we asked whether absence of platelet serotonin affects neutrophil recruitment in inflammatory responses. Tryptophan hydroxylase (Tph)1–deficient mice, lacki...

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Autori principali: Duerschmied, Daniel, Suidan, Georgette L., Demers, Melanie, Herr, Nadine, Carbo, Carla, Brill, Alexander, Cifuni, Stephen M., Mauler, Maximilian, Cicko, Sanja, Bader, Michael, Idzko, Marco, Bode, Christoph, Wagner, Denisa D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2013
Soggetti:
Phagocytes, Granulocytes, and Myelopoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567335/
https://ncbi.nlm.nih.gov/pubmed/23243271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-06-437392
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