Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow

E-selectin extends from the plasma membrane of inflamed endothelium and serves to capture leukocytes from flowing blood via long-lived catch-bonds that support slow leukocyte rolling under shear stress. Its ligands are glycosylated with the tetrasaccharide sialyl Lewis(x) (sLe(x)), which contributes...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Morikis, Vasilios A., Chase, Shannon, Wun, Ted, Chaikof, Elliot L., Magnani, John L., Simon, Scott I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680610/
https://ncbi.nlm.nih.gov/pubmed/28811304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-783027
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