Tyrosine kinase Btk regulates E-selectin–mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) γ2 and PI3Kγ pathways

Selectins mediate leukocyte rolling, trigger β(2)-integrin activation, and promote leukocyte recruitment into inflamed tissue. E-selectin binding to P-selectin glycoprotein ligand 1 (PSGL-1) leads to activation of an immunoreceptor tyrosine-based activation motif (ITAM)–dependent pathway, which in t...

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Detalhes bibliográficos
Main Authors: Mueller, Helena, Stadtmann, Anika, Van Aken, Hugo, Hirsch, Emilio, Wang, Demin, Ley, Klaus, Zarbock, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858472/
https://ncbi.nlm.nih.gov/pubmed/20167705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-254185
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