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LFA-1, kindlin-3 and calcium flux orchestrate neutrophil recruitment during inflammation
Neutrophil arrest and migration on inflamed endothelium involves a conformational shift in CD11a/CD18 (LFA-1) to a high affinity and clustered state that determines the strength and lifetime of bond formation with ICAM-1. Cytoskeletal adaptor proteins Kindlin-3 and Talin-1 anchor clustered LFA-1 to...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3723394/ https://ncbi.nlm.nih.gov/pubmed/23144497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201638 |
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