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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
The mTORC1 kinase promotes growth in response to growth factors, energy levels, and amino acids and its activity is often deregulated in disease. The Rag GTPases interact with mTORC1 and are proposed to activate it in response to amino acids by promoting mTORC1 translocation to a membrane-bound comp...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024592/ https://ncbi.nlm.nih.gov/pubmed/20381137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.02.024 |
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