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Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T-cell recognition
Improving T-cell antigens by altering MHC anchor residues is a common strategy used to enhance peptide vaccines but there has been little assessment of how such modifications affect TCR binding and T-cell recognition. Here, we use surface plasmon resonance and peptide-MHC tetramer binding at the cel...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024538/ https://ncbi.nlm.nih.gov/pubmed/20639478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000629 |
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