Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T-cell recognition

Improving T-cell antigens by altering MHC anchor residues is a common strategy used to enhance peptide vaccines but there has been little assessment of how such modifications affect TCR binding and T-cell recognition. Here, we use surface plasmon resonance and peptide-MHC tetramer binding at the cel...

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Autors principals: Cole, David K, Edwards, Emily SJ, Wynn, Katherine K, Clement, Mathew, Miles, John J, Ladell, Kristin, Ekeruche, Julia, Gostick, Emma, Adams, Katherine, Skowera, Ania, Peakman, Mark, Wooldridge, Linda, Price, David A, Sewell, Andrew K
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024538/
https://ncbi.nlm.nih.gov/pubmed/20639478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000629
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