Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T-cell recognition

Improving T-cell antigens by altering MHC anchor residues is a common strategy used to enhance peptide vaccines but there has been little assessment of how such modifications affect TCR binding and T-cell recognition. Here, we use surface plasmon resonance and peptide-MHC tetramer binding at the cel...

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Bibliografiska uppgifter
Huvudupphovsmän: Cole, David K, Edwards, Emily SJ, Wynn, Katherine K, Clement, Mathew, Miles, John J, Ladell, Kristin, Ekeruche, Julia, Gostick, Emma, Adams, Katherine, Skowera, Ania, Peakman, Mark, Wooldridge, Linda, Price, David A, Sewell, Andrew K
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024538/
https://ncbi.nlm.nih.gov/pubmed/20639478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000629
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