Ribosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial cells

Diabetes promotes protein synthesis to induce kidney hypertrophy and increase renal matrix proteins. Increased capacity for mRNA translation by way of ribosomal biogenesis facilitates sustained stimulation of protein synthesis. We tested the hypothesis that high glucose induces ribosomal biogenesis...

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Main Authors: Mariappan, Meenalakshmi M., D'Silva, Kristin, Lee, Myung Ja, Sataranatarajan, Kavithalakshmi, Barnes, Jeffrey L., Choudhury, Goutam Ghosh, Kasinath, Balakuntalam S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023218/
https://ncbi.nlm.nih.gov/pubmed/20943765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00207.2010
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