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Glycogen Synthase Kinase 3β Is a Novel Regulator of High Glucose- and High Insulin-induced Extracellular Matrix Protein Synthesis in Renal Proximal Tubular Epithelial Cells

High glucose (30 mm) and high insulin (1 nm), pathogenic factors of type 2 diabetes, increased mRNA expression and synthesis of lamininβ1 and fibronectin after 24 h of incubation in kidney proximal tubular epithelial (MCT) cells. We tested the hypothesis that inactivation of glycogen synthase kinase...

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Autors principals: Mariappan, Meenalakshmi M., Shetty, Megan, Sataranatarajan, Kavithalakshmi, Choudhury, Goutam Ghosh, Kasinath, Balakuntalam S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576557/
https://ncbi.nlm.nih.gov/pubmed/18701453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801756200
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