Tadalafil Integrates Nitric Oxide-Hydrogen Sulfide Signaling to Inhibit High Glucose-induced Matrix Protein Synthesis in Podocytes

Diabetes-induced kidney cell injury involves an increase in matrix protein expression that is only partly alleviated by current treatment, prompting a search for new modalities. We have previously shown that hydrogen sulfide (H(2)S) inhibits high glucose-induced protein synthesis in kidney podocytes...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Lee, Hak Joo, Feliers, Denis, Mariappan, Meenalakshmi M., Sataranatarajan, Kavithalakshmi, Choudhury, Goutam Ghosh, Gorin, Yves, Kasinath, Balakuntalam S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424338/
https://ncbi.nlm.nih.gov/pubmed/25752605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.615377
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