Regulation of Elongation Phase of mRNA Translation in Diabetic Nephropathy : Amelioration by Rapamycin

High glucose and high insulin, pathogenic factors in type 2 diabetes, induce rapid synthesis of the matrix protein laminin-β1 in renal proximal tubular epithelial cells by stimulation of initiation phase of mRNA translation. We investigated if elongation phase of translation also contributes to high...

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Main Authors: Sataranatarajan, Kavithalakshmi, Mariappan, Meenalakshmi M., Lee, Myung Ja, Feliers, Denis, Choudhury, Goutam Ghosh, Barnes, Jeffrey L., Kasinath, Balakuntalam S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2111098/
https://ncbi.nlm.nih.gov/pubmed/17991718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070412
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