The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8

Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance pathway that regulates the degradation of mRNAs harboring premature translation termination codons. NMD also influences the expression of many physiological transcripts. SMG-1 is a large kinase essential to NMD that phosphorylates Upf1,...

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Autores principales: Arias-Palomo, Ernesto, Yamashita, Akio, Fernández, Israel S., Núñez-Ramírez, Rafael, Bamba, Yumi, Izumi, Natsuko, Ohno, Shigeo, Llorca, Oscar
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2011
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022261/
https://ncbi.nlm.nih.gov/pubmed/21245168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.606911
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