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Pseudophosphorylation of tau protein directly modulates its aggregation kinetics

Hyperphosphorylation of tau protein is associated with neurofibrillary lesion formation in Alzheimer’s disease and other tauopathic neurodegenerative diseases. It fosters lesion formation by increasing the concentration of free tau available for aggregation and by directly modulating the tau aggrega...

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Détails bibliographiques
Auteurs principaux: Chang, Edward, Kim, Sohee, Schafer, Kelsey N., Kuret, Jeff
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018534/
https://ncbi.nlm.nih.gov/pubmed/20974297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2010.10.005
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