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Structural insights into human mitochondrial DNA replication and disease-related polymerase mutations
Human mitochondrial DNA polymerase (Pol γ) is the sole replicase in mitochondria. Pol γ is vulnerable to non-selective anti-retroviral drugs and is increasingly associated with mutations from mitochondriopathic patients. We determined a crystal structure of human Pol γ holoenzyme and, separately, a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018533/ https://ncbi.nlm.nih.gov/pubmed/19837034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.07.050 |
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