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Oxidative damage diminishes mitochondrial DNA polymerase replication fidelity
Mitochondrial DNA (mtDNA) resides in a high ROS environment and suffers more mutations than its nuclear counterpart. Increasing evidence suggests that mtDNA mutations are not the results of direct oxidative damage, rather are caused, at least in part, by DNA replication errors. To understand how the...
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| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6954441/ https://ncbi.nlm.nih.gov/pubmed/31799610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1018 |
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