Calcium-driven DNA synthesis by a high-fidelity DNA polymerase

Divalent metal ions, usually Mg(2+), are required for both DNA synthesis and proofreading functions by DNA polymerases (DNA Pol). Although used as a non-reactive cofactor substitute for binding and crystallographic studies, Ca(2+) supports DNA polymerization by only one DNA Pol, Dpo4. Here, we explo...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Ralec, Céline, Henry, Etienne, Lemor, Mélanie, Killelea, Tom, Henneke, Ghislaine
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716173/
https://ncbi.nlm.nih.gov/pubmed/29040737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx927
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