Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase ζ

To probe Pol ζ functions in vivo via its error signature, here we report the properties of Saccharomyces cerevisiae Pol ζ in which phenyalanine was substituted for the conserved Leu-979 in the catalytic (Rev3) subunit. We show that purified L979F Pol ζ is 30% as active as wild-type Pol ζ when replic...

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Main Authors: Stone, Jana E., Kissling, Grace E., Lujan, Scott A., Rogozin, Igor B., Stith, Carrie M., Burgers, Peter M. J., Kunkel, Thomas A.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2009
主題:
Nucleic Acids Enzymes
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699522/
https://ncbi.nlm.nih.gov/pubmed/19380376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp238
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