Low-fidelity DNA synthesis by human DNA polymerase theta

Human DNA polymerase theta (pol θ or POLQ) is a proofreading-deficient family A enzyme implicated in translesion synthesis (TLS) and perhaps in somatic hypermutation (SHM) of immunoglobulin genes. These proposed functions and kinetic studies imply that pol θ may synthesize DNA with low fidelity. Her...

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Bibliographic Details
Main Authors: Arana, Mercedes E., Seki, Mineaki, Wood, Richard D., Rogozin, Igor B., Kunkel, Thomas A.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441791/
https://ncbi.nlm.nih.gov/pubmed/18503084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn310
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