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Low-fidelity DNA synthesis by human DNA polymerase theta
Human DNA polymerase theta (pol θ or POLQ) is a proofreading-deficient family A enzyme implicated in translesion synthesis (TLS) and perhaps in somatic hypermutation (SHM) of immunoglobulin genes. These proposed functions and kinetic studies imply that pol θ may synthesize DNA with low fidelity. Her...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2441791/ https://ncbi.nlm.nih.gov/pubmed/18503084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn310 |
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