Carregando...
Structural insights into human mitochondrial DNA replication and disease-related polymerase mutations
Human mitochondrial DNA polymerase (Pol γ) is the sole replicase in mitochondria. Pol γ is vulnerable to non-selective anti-retroviral drugs and is increasingly associated with mutations from mitochondriopathic patients. We determined a crystal structure of human Pol γ holoenzyme and, separately, a...
Na minha lista:
| Principais autores: | , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018533/ https://ncbi.nlm.nih.gov/pubmed/19837034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.07.050 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|