Impairment of Methotrexate Transport Is Common in Osteosarcoma Tumor Samples

Osteosarcoma does not respond well to conventional dose methotrexate but does respond to high-dose methotrexate. Previous work has indicated that this resistance may be due to impaired transport of methotrexate across the cell membrane. In this study, the PT430 competitive displacement assay was ada...

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Bibliografske podrobnosti
Main Authors: Sowers, Rebecca, Wenzel, Bethanne D., Richardson, Condon, Meyers, Paul A., Healey, John H., Levy, Adam S., Gorlick, Richard
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017953/
https://ncbi.nlm.nih.gov/pubmed/21234348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/834170
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