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Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma
Inter-individual differences in toxic symptoms and pharmacokinetics of high-dose methotrexate (MTX) treatment may be caused by genetic variants in the MTX pathway. Correlations between polymorphisms and pharmacokinetic parameters and the occurrence of hepato- and myelotoxicity were studied. Single n...
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Publicado no: | Oncotarget |
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Main Authors: | , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Impact Journals LLC
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5354739/ https://ncbi.nlm.nih.gov/pubmed/27566582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11543 |
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