Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma

Inter-individual differences in toxic symptoms and pharmacokinetics of high-dose methotrexate (MTX) treatment may be caused by genetic variants in the MTX pathway. Correlations between polymorphisms and pharmacokinetic parameters and the occurrence of hepato- and myelotoxicity were studied. Single n...

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Publicado en:Oncotarget
Autores principales: Hegyi, Marta, Arany, Adam, Semsei, Agnes F., Csordas, Katalin, Eipel, Oliver, Gezsi, Andras, Kutszegi, Nora, Csoka, Monika, Muller, Judit, Erdelyi, Daniel J., Antal, Peter, Szalai, Csaba, Kovacs, Gabor T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354739/
https://ncbi.nlm.nih.gov/pubmed/27566582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11543
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