Impairment of Methotrexate Transport Is Common in Osteosarcoma Tumor Samples

Osteosarcoma does not respond well to conventional dose methotrexate but does respond to high-dose methotrexate. Previous work has indicated that this resistance may be due to impaired transport of methotrexate across the cell membrane. In this study, the PT430 competitive displacement assay was ada...

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Detalhes bibliográficos
Main Authors: Sowers, Rebecca, Wenzel, Bethanne D., Richardson, Condon, Meyers, Paul A., Healey, John H., Levy, Adam S., Gorlick, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017953/
https://ncbi.nlm.nih.gov/pubmed/21234348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/834170
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