Impairment of Methotrexate Transport Is Common in Osteosarcoma Tumor Samples

Osteosarcoma does not respond well to conventional dose methotrexate but does respond to high-dose methotrexate. Previous work has indicated that this resistance may be due to impaired transport of methotrexate across the cell membrane. In this study, the PT430 competitive displacement assay was ada...

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Detaylı Bibliyografya
Asıl Yazarlar: Sowers, Rebecca, Wenzel, Bethanne D., Richardson, Condon, Meyers, Paul A., Healey, John H., Levy, Adam S., Gorlick, Richard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Hindawi Publishing Corporation 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017953/
https://ncbi.nlm.nih.gov/pubmed/21234348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/834170
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