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Polymorphisms and Methylation of the Reduced Folate Carrier in Osteosarcoma
High-dose methotrexate is a standard component in the treatment of osteogenic sarcoma. Impaired methotrexate uptake associated with decreased reduced folate carrier expression is a common mechanism of methotrexate resistance in osteogenic sarcoma samples. We investigated whether promoter methylation...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2493020/ https://ncbi.nlm.nih.gov/pubmed/18528741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11999-008-0323-3 |
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