TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain

DNA double-strand breaks enhance homologous recombination in cells and have been exploited for targeted genome editing through use of engineered endonucleases. Here we report the creation and initial characterization of a group of rare-cutting, site-specific DNA nucleases produced by fusion of the r...

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Библиографические подробности
Главные авторы: Li, Ting, Huang, Sheng, Jiang, Wen Zhi, Wright, David, Spalding, Martin H., Weeks, Donald P., Yang, Bing
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2011
Предметы:
Synthetic Biology and Chemistry
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017587/
https://ncbi.nlm.nih.gov/pubmed/20699274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq704
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