Re-engineered RNA-Guided FokI-Nucleases for Improved Genome Editing in Human Cells

Clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 enables us to generate targeted sequence changes in the genomes of cells and organisms. However, off-target effects have been a persistent problem hampering the development of therapeutics based on CRISPR/Cas9 and potentially confound...

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Veröffentlicht in:Mol Ther
Hauptverfasser: Havlicek, Steven, Shen, Yang, Alpagu, Yunus, Bruntraeger, Michaela B., Zufir, Nurdiana B.M., Phuah, Zhi Yi, Fu, Zhiyan, Dunn, Norris R., Stanton, Lawrence W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368403/
https://ncbi.nlm.nih.gov/pubmed/28153087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.11.007
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