Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

Recent studies indicate that the DNA recognition domain of transcription activator-like (TAL) effectors can be combined with the nuclease domain of FokI restriction enzyme to produce TAL effector nucleases (TALENs) that, in pairs, bind adjacent DNA target sites and produce double-strand breaks betwe...

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Bibliographic Details
Main Authors: Li, Ting, Huang, Sheng, Zhao, Xuefeng, Wright, David A., Carpenter, Susan, Spalding, Martin H., Weeks, Donald P., Yang, Bing
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Synthetic Biology and Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152341/
https://ncbi.nlm.nih.gov/pubmed/21459844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr188
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