Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

Recent studies indicate that the DNA recognition domain of transcription activator-like (TAL) effectors can be combined with the nuclease domain of FokI restriction enzyme to produce TAL effector nucleases (TALENs) that, in pairs, bind adjacent DNA target sites and produce double-strand breaks betwe...

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Detalhes bibliográficos
Main Authors: Li, Ting, Huang, Sheng, Zhao, Xuefeng, Wright, David A., Carpenter, Susan, Spalding, Martin H., Weeks, Donald P., Yang, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Synthetic Biology and Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152341/
https://ncbi.nlm.nih.gov/pubmed/21459844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr188
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