Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

Recent studies indicate that the DNA recognition domain of transcription activator-like (TAL) effectors can be combined with the nuclease domain of FokI restriction enzyme to produce TAL effector nucleases (TALENs) that, in pairs, bind adjacent DNA target sites and produce double-strand breaks betwe...

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Bibliographische Detailangaben
Hauptverfasser: Li, Ting, Huang, Sheng, Zhao, Xuefeng, Wright, David A., Carpenter, Susan, Spalding, Martin H., Weeks, Donald P., Yang, Bing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
Schlagworte:
Synthetic Biology and Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152341/
https://ncbi.nlm.nih.gov/pubmed/21459844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr188
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