Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes

TAL Effector Nucleases (TALENs) are versatile tools for targeted gene editing in various species. However, their efficiency is still insufficient, especially in mammalian embryos. Here, we showed that combined expression of Exonuclease 1 (Exo1) with engineered site-specific TALENs provided highly ef...

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Autors principals: Mashimo, Tomoji, Kaneko, Takehito, Sakuma, Tetsushi, Kobayashi, Junya, Kunihiro, Yayoi, Voigt, Birger, Yamamoto, Takashi, Serikawa, Tadao
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570776/
https://ncbi.nlm.nih.gov/pubmed/23409244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01253
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