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Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes
TAL Effector Nucleases (TALENs) are versatile tools for targeted gene editing in various species. However, their efficiency is still insufficient, especially in mammalian embryos. Here, we showed that combined expression of Exonuclease 1 (Exo1) with engineered site-specific TALENs provided highly ef...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3570776/ https://ncbi.nlm.nih.gov/pubmed/23409244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01253 |
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