Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes

TAL Effector Nucleases (TALENs) are versatile tools for targeted gene editing in various species. However, their efficiency is still insufficient, especially in mammalian embryos. Here, we showed that combined expression of Exonuclease 1 (Exo1) with engineered site-specific TALENs provided highly ef...

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Autori principali: Mashimo, Tomoji, Kaneko, Takehito, Sakuma, Tetsushi, Kobayashi, Junya, Kunihiro, Yayoi, Voigt, Birger, Yamamoto, Takashi, Serikawa, Tadao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570776/
https://ncbi.nlm.nih.gov/pubmed/23409244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01253
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