Generation of Knockout Rats with X-Linked Severe Combined Immunodeficiency (X-SCID) Using Zinc-Finger Nucleases

BACKGROUND: Although the rat is extensively used as a laboratory model, the inability to utilize germ line-competent rat embryonic stem (ES) cells has been a major drawback for studies that aim to elucidate gene functions. Recently, zinc-finger nucleases (ZFNs) were successfully used to create genom...

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Detalhes bibliográficos
Main Authors: Mashimo, Tomoji, Takizawa, Akiko, Voigt, Birger, Yoshimi, Kazuto, Hiai, Hiroshi, Kuramoto, Takashi, Serikawa, Tadao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810328/
https://ncbi.nlm.nih.gov/pubmed/20111598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008870
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