Generation of Knockout Rats with X-Linked Severe Combined Immunodeficiency (X-SCID) Using Zinc-Finger Nucleases

BACKGROUND: Although the rat is extensively used as a laboratory model, the inability to utilize germ line-competent rat embryonic stem (ES) cells has been a major drawback for studies that aim to elucidate gene functions. Recently, zinc-finger nucleases (ZFNs) were successfully used to create genom...

Full description

Saved in:
Bibliographic Details
Main Authors: Mashimo, Tomoji, Takizawa, Akiko, Voigt, Birger, Yoshimi, Kazuto, Hiai, Hiroshi, Kuramoto, Takashi, Serikawa, Tadao
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810328/
https://ncbi.nlm.nih.gov/pubmed/20111598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008870
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items